Endocrine Abstracts

Background: Gestational Diabetes Mellitus (GDM) is one of the most common illness of pregnancy. Despite its frequency, there’s no worldwide accepted screening criteria for GDM. In 2011, Carpenter and Coustan (CC) screening (50-g glucose challenge test (GCT) followed by 100-g glucose tolerance test (OGTT) if GCT screen was positive) was abandoned and began the implementation of the screening of the International Association of Diabetes and Pregnancy Study Group (IADPSG) 20...

Introduction: Acromegaly is usually caused by a pituitary adenoma; ectopic or eutopic secretion of GHRH is a rare condition, responsible for <1% of the cases. Ectopic secretion of GH itself is even rarer.Case report: A 34-year-old woman was referred to the Endocrine Clinic with a multinodular goiter. However, on physical examination there were some physical signs of acromegaly: coarsening of facial features, protusion of the lower jaw and thick, oily...

Introduction: The acute onset of pulmonary edema and severe congestive heart failure secondary to catecholamine overproduction from a pheochromocytoma is a rare entity, especially in the absence of other signs or symptoms suspicious of this tumour. Myocardial involvement can include angina pectoris, acute heart failure, dilated cardiomyopathy, myocardial infartion and arrhytmias. Here, we present the case of a young man with no significant medical history who presented with ac...

Mitochondrial diseases are rare conditions with a wide phenotypic range. The inability of dysfunctional mitochondria to produce sufficient ATP results in multi-organic defects dependent on high aerobic such as pancreas. The most common endocrine disease related to mitochondrial diseases is diabetes mellitus and it is thought to be secondary to insulin deficiency. A 26-year-old pregnant patient with 26 weeks gestational age was referred to an Endocrinology appointment ...

Background: Immune checkpoint inhibitors (ICI) are an innovative oncologic therapy used in several types of solid and hematological neoplasms. This treatment enables the antitumoral immune system response and results in significant improvement of clinical outcomes and survival rate. However, endocrine related adverse effects (ERAE) have been related, with thyroid and pituitary dysfunction being the most common endocrine diseases described. An association between the surge of e...